Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

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Changing nutrient environments challenge cells as they affect both protein biosynthesis and cell cycle length. This work ...

Treatment with OTX-2002 led to controlled downregulation of MYC gene expression and resulted in significant inhibition of ...

RNA vaccines are just the tip of the iceberg. Ruby Jackson discusses how this versatile molecule is revolutionising medicine ...

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising ...

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

ExPLoRNA Therapeutics specialises in mRNA innovations, focusing on new cap analogues that are crucial for successful protein ...