Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

It all started in the lab. Two Boston University doctoral students, Joshua McGee and Jack Kirsch, were creating and testing ...

An accidental discovery turned into an unexpected success when a team of interdisciplinary BU researchers created a new and ...

mRNA vaccines and therapeutics are rapidly growing, driven by the success of COVID-19 vaccines. The 5’ cap structure is crucial for mRNA stability and expression. However, in-vitro transcribed mRNA ...

RNA-sequencing has become a cornerstone in the study of gene expression, offering insights beyond mere mRNA transcript ...

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases. However, siRNA drugs have challenges because siRNAs often silence ...

They decided to focus on modifying the chemical structure of a lesser-known type of RNA ... and at the same time the immune system is degrading it,” says Grinstaff. Standard mRNA COVID vaccines tell ...

RNA vaccines are just the tip of the iceberg. Ruby Jackson discusses how this versatile molecule is revolutionising medicine ...

Small interfering RNA (siRNA) drugs are a class of therapeutic agents that silence specific genes associated with inherited diseases.

The end-to-end platform facilitates the study of therapeutic translation, stability-influencing structure, mRNA substance identity and integrity, and lipid nanoparticle and storage effects. In ...