mRNA-based therapeutics: powerful and versatile tools to combat ...
WEBMay 21, 2022 · The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the...
Unlocking the promise of mRNA therapeutics - Nature
WEBNov 3, 2022 · Early clinical trials of mRNA therapeutics include studies of paracrine vascular endothelial growth factor (VEGF) mRNA for heart failure and of CRISPR–Cas9 mRNA for a congenital...
mRNA-based therapeutics: powerful and versatile tools to combat ...
WEBMay 21, 2022 · The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in biotechnology and molecular medicine have enabled the production of almost any functional protein/peptide in the human body by introducing mRNA as a vaccine or therapeutic agent.
mRNA Technology: What It Is and How It Works - Pfizer
WEBHow do mRNA therapeutics like the COVID-19 vaccine work? What else can mRNA help us treat? This three-part series answers these questions and more. Meet mRNA. How This Once Little-Known Molecule Is Disrupting Medicine. Explore What’s Next for mRNA. Unlocking the Power of Our Body's Protein Factory. Discover Custom Trucks.
mRNA-based therapeutics: looking beyond COVID-19 vaccines
WEBHere, we will summarise the recent advances in mRNA technology; its use in vaccines, immunotherapeutics, protein replacement therapy, and genomic editing; and its delivery to desired specific cell types and organs for development of a new generation of targeted mRNA-based therapeutics.
mRNA therapy at the convergence of genetics and nanomedicine
WEBMar 17, 2023 · The ability of mRNA therapeutics to better link the biology of human physiological systems with new mRNA payloads and in vivo nanodelivery systems, by providing options for continuous dosage...
RNA Therapy: Current Status and Future Potential - PMC
WEBMay 25, 2020 · RNA therapy has many advantages over existing small molecule or monoclonal antibody-based therapies, including its potential to target all genes in the cells. This review will introduce the history of RNA therapy, and explain the basic concepts of RNA therapy and RNA-based drugs on the market or clinical trials.
mRNA therapeutics for disease therapy: principles, delivery, and ...
WEBApr 26, 2023 · Messenger RNA (mRNA) has become a key focus in the development of therapeutic agents, showing significant potential in preventing and treating a wide range of diseases. The COVID-19 pandemic in 2020 has accelerated the development of mRNA nucleic therapeutics and attracted significant investment fro ….
mRNA, a Revolution in Biomedicine - PMC - National Center for ...
WEBDec 5, 2021 · To achieve the goal of an effective mRNA-based therapy, meaning the reestablishment of the production of a missing or defective protein, it is necessary that mRNA enter the cells, leading to the target protein expression at therapeutic levels.
mRNA-based therapeutics: powerful and versatile tools to combat ...
WEBMay 21, 2022 · We also highlight the importance of mRNA optimization and delivery systems in successful mRNA therapeutics and discuss the key challenges and opportunities in developing these tools into powerful and versatile tools to combat many genetic, infectious, cancer, and other refractory diseases.
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