mRNA Vaccines: A Bright Future in Vaccinology | Penn Medicine
WEBPenn Medicine is home to the breakthrough messenger ribonucleic acid (mRNA) technology that enabled the highly successful COVID-19 vaccines from Moderna and Pfizer-BioNTech. Now the path is set for a whole new class of mRNA vaccines with the potential to eradicate countless other diseases, even …
Alliance for mRNA Medicines
WEBThe Alliance for mRNA Medicines (AMM) is the leading global organization dedicated to advancing and advocating for mRNA and next-generation encoding RNA therapeutics and vaccines for the benefit of patients, public health, and society.
mRNA-based therapeutics: powerful and versatile tools to combat ...
WEBMay 21, 2022 · Messenger RNA (mRNA) is a type of single-stranded ribonucleic acid that is transcribed from a strand of DNA, which carries the coding information for protein synthesis to be further...
What are mRNA vaccines and how do they work? - MedlinePlus
WEBmRNA vaccines work by introducing a piece of mRNA that corresponds to a viral protein, usually a small piece of a protein found on the virus’s outer membrane. (Individuals who get an mRNA vaccine are not exposed to the virus, nor can they become infected with the virus by the vaccine.) By using this mRNA, cells can produce the viral protein.
mRNA vaccines in disease prevention and treatment
WEBSep 20, 2023 · Vaccines using messenger RNA (mRNA), a single nucleotide sequence that functions as a template for protein translation, possess multiple beneficial features over traditional vaccines. 3, 8...
mRNA, a Revolution in Biomedicine - PMC - National Center for ...
WEBDec 5, 2021 · 2. mRNA Structure and Biogenesis. Several types of RNA play fundamental roles in gene expression, a process responsible for the use of information stored in the DNA sequence to produce effector molecules, such as RNAs and proteins, which are the basis of cell biology [].The central dogma of molecular biology states that DNA is transcribed into mRNA, which is later translated into proteins [].
mRNA vaccines for infectious diseases: principles, delivery and ...
WEBAug 25, 2021 · Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid...
Understanding COVID-19 mRNA Vaccines - National Human …
WEBAug 30, 2021 · Fact Sheet. Understanding COVID-19 mRNA Vaccines. Messenger RNA (mRNA) is a molecule that encodes a sequence that can be made into a protein. Scientists first learned about mRNA nearly 60 years ago, and researchers have been studying vaccines using mRNA for decades.
RNA ‐based medicine: from molecular mechanisms to therapy
WEBSep 20, 2023 · We have now reached a pivotal moment where RNA medicines are poised to make a broad impact in the clinic. In this review, we present an overview of different RNA‐based strategies to generate novel therapeutics, including antisense and RNAi‐based mechanisms, mRNA‐based approaches, and CRISPR‐Cas‐mediated genome editing.
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
WEBJul 14, 2020 · The candidate vaccine mRNA-1273 encodes the stabilized prefusion SARS-CoV-2 spike protein. Methods. We conducted a phase 1, dose-escalation, open-label trial including 45 healthy adults, 18 to 55...